Diabetic Cardiomyopathy: Catabolism Driving Metabolism Running title: Wang et al.; Diabetic Cardiomyopathy: Catabolism and Metabolism
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Diabetic cardiomyopathy: role of the E3 ubiquitin ligase.
Diabetic cardiomyopathy (DCM) is the leading cause of mortality in diabetes. As the number of cases of diabetes continues to rise, it is urgent to develop new strategies to protect against DCM, which is characterized by cardiac hypertrophy, increased apoptosis, fibrosis, and altered insulin metabolism. The E3 ubiquitin ligases (E3s), one component of the ubiquitin-proteasome system, play vital ...
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Multiple factors have been shown to promote the progression of diabetic cardiomyopathy. A link has previously been found between Mir30 and autophagy in cancer cells and in the heart, but the role of Mir30 in diabetic heart has not been studied. Using in vitro and in vivo approaches, we found that the depletion of Mir30c and induction of BECN1 enhanced autophagy in diabetic (db/db) hearts and in...
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The incidence of type 2 diabetes is increasing explosively around the world. Both hyperglycemia and insulin resistance can cause myocardial damages with coronary atherosclerosis in type 2 diabetes. In addition, some patients show cardiac functional disorder, characterized by diastolic dysfunction, without ischemia. In a large prospective study in the Framingham cohort, patients with diabetes sh...
متن کاملInvited Review Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
An, Ding, and Brian Rodrigues. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 291: H1489– H1506, 2006. First published June 2, 2006; doi:10.1152/ajpheart.00278.2006.—In patients with diabetes, an increased risk of symptomatic heart failure usually develops in the presence of hypertension or ischemic heart disease. However, a pred...
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1 From Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, China 215123. 2 Lawson Health Research Institute, Departments of 3 Medicine, 4 Pathology, 5 Biology, University of Western Ontario, London, Ontario, Canada N6A 4G5. 6 Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA 45267-0575. 7 Key L...
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